Association between interleukin-15 polymorphisms and susceptibility to rheumatoid arthritis in a Chinese population

作者：Zhou, Xindie; Wang, Mingjie; Zhang, Hui; Liu, Ruiping^*; Fan, Weimin^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(5): 8656-8663.

• Interleukin-15
• polymorphism
• rheumatoid arthritis
• molecular epidemiology

Background: An association between interleukin-15 (IL-15) polymorphisms and the prevalence of rheumatoid arthritis (RA) in Caucasians has been reported. We hypothesized that IL-15 polymorphisms might also affect RA susceptibility in the Chinese population. Methods: We studied the IL-15 rs10519612 A/C, rs10519613 C/A, rs17007695 T/C, rs17015014 G/C, rs35964658 A/G, and rs2228059 T/G polymorphisms in 615 RA patients and 839 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex SNPscan (TM) Kit. Results: Our results indicated that the IL-15 rs17007695 polymorphism was associated with RA, and the IL-15 rs17007695 CC genotype decreased the risk of RA. No significant associations were observed between the IL-15 rs10519612 A/C, rs10519613 C/A, rs17015014 G/C, rs35964658 A/G, or rs2228059 T/G polymorphisms and RA. The IL-15 rs17007695 CC genotype was associated with a significantly decreased RA risk, especially among male, rheumatoid factor (RF)-positive, DAS28 >= 3.20, and functional class I/II patients. The IL-15 rs17007695 C allele was also associated with a significantly decreased RA risk among >= 55 year-old patients, CRP-negative, anticyclic citrullinated peptide antibody (ACPA)-positive, and erythrocyte sedimentation rate (ESR) <25.00 patients. Conclusions: These findings suggest that IL-15 polymorphisms are associated with RA. Future larger studies of other ethnic populations are required to confirm these findings.

• 出版日期2016
• 单位南京医科大学