A Case of Refractory Chronic Respiratory Tract Infection due to Pseudomonas aeruginosa Successfully Controlled by Combination of Clarithromycin and Azithromycin

作者：Yamamoto Yoshihiro; Izumikawa Koichi^*; Hosogaya Naoki; Morinaga Yoshitomo; Nakamura Shigeki; Imamura Yoshifumi; Miyazaki Taiga; Sakamoto Noriho; Ishimatu Yuji; Kakeya Hiroshi; Yanagihara Katsunori; Yasuoka Akira; Kohno Shigeru

来源：Internal Medicine, 2012, 51(11): 1383-1386.

DOI：10.2169/internalmedicine.51.6985

• chronic respiratory tract infection
• Pseudomonas aeruginosa
• clarithromycin
• azithromycin

The prognosis of patients with chronic respiratory tract infections, especially diffuse panbronchiolitis, is remarkably improved by long-term administration of low-dose macrolides. However, in some cases, patients are refractory to macrolide treatment and show a low or no response; therefore, new treatment strategies are required. Here we present a patient refractory to either single low-dose clarithromycin or azithromycin but responded remarkably to the combination usage of both macrolides.

• 出版日期2012