Applications of Chemical Ligation in Peptide Synthesis via Acyl Transfer

作者：Panda Siva S^*; Jones Rachel A; Hall C Dennis; Katritzky Alan R

来源：PROTEIN LIGATION AND TOTAL SYNTHESIS I, SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY, 229-265, 2015.

DOI：10.1007/128_2014_608

• Acyl migration
• Acyl transfer
• Chemical ligation
• Computational studies
• Cyclic peptides
• Glycopeptides
• Neoglycoconjugates
• SPPS

The utility of native chemical ligation (NCL) in the solution or solid phase synthesis of peptides, cyclic peptides, glycopeptides, and neoglycoconjugates is reviewed. In addition, the mechanistic details of inter- or intra-molecular NCLs are discussed from experimental and computational points of view.

• 出版日期2015