Assessment of Size and Morphological Effects of Ceramics Nanoparticles on Their Biocompatibility

作者：Tsuchiya Satoshi; Abe Shigeaki^*; Era Yuko; Nakagawa Yukari; Yamagata Shuichi; Nakamura Mariko; Kusaka Teruo; Yoshida Yasuhiro; Yonezawa Tetsu; Iida Junichiro

来源：Nanoscience and Nanotechnology Letters, 2016, 8(4): 329-334.

DOI：10.1166/nnl.2016.2139

• Ceramics Nanoparticle
• Biocompatibility
• Topological Properties
• Surface Modification

In this study, we investigated the effects of the topological properties of ceramics nanoparticles (NPs) (i.e., TiO2, Fe2O3, and CuO) on their biocompatibility. In the case of particle size, cell viability was not affected by the size of TiO2 particles even when the size was varied from 30 to 250 nm. Although the cytocompatibilities of TiO2 NPs with different morphologies were compared, no substantial difference was observed. In the case of Fe2O3, the viability decreased slightly with increasing particle concentration without a particle-size effect. In contrast, the viability upon exposure to CuO NPs decreased drastically with increasing NP concentration. Furthermore, the viability improved when CuO NPs size was increased from the nano-regime to micro-regime. Interestingly, greater viability was exhibited by gelatin-coated Cu NPs than by CuO NPs. These results suggest that the cytocompatibility of ceramics NPs is more strongly affected by chemical species than by particle size and, morphology.

• 出版日期2016-4