Dynamics of single-cell gene expression

作者：Longo Diane; Hasty Jeff^*

来源：Molecular Systems Biology, 2006, 2(1): 64.

DOI：10.1038/msb4100110

• gene expression
• noise
• single cell

Cellular behavior has traditionally been investigated by utilizing bulk-scale methods that measure average values for a population of cells. Such population-wide studies mask the behavior of individual cells and are often insufficient for characterizing biological processes in which cellular heterogeneity plays a key role. A unifying theme of many recent studies has been a focus on the development and utilization of single-cell experimental techniques that are capable of probing key biological phenomena in individual living cells. Recently, novel information about gene expression dynamics has been obtained from single-cell experiments that draw upon the unique capabilities of fluorescent reporter proteins.

• 出版日期2006