Antimicrobial Activity of Ceftaroline and Other Anti-Infective Agents against Microbial Pathogens Recovered from the Surgical Intensive Care Patient Population: A Prevalence Analysis

作者：Edmiston Charles E Jr^*; Krepel Candace J; Leaper David; Ledeboer Nathan A; Mackey Tami Lea; Graham Mary Beth; Lee Cheong; Rossi Peter J; Brown Kellie R; Lewis Brian D; Seabrook Gary R

来源：Surgical Infections, 2014, 15(6): 745-751.

DOI：10.1089/sur.2013.172

Background: Ceftaroline is a new parenteral cephalosporin agent with excellent activity against methicillin-sensitive (MSSA) and resistant strains of Staphylococcus aureus (MRSA). Critically ill surgical patients are susceptible to infection, often by multi-drug-resistant pathogens. The activity of ceftaroline against such pathogens has not been described. %26lt;br%26gt;Methods: Three hundred thirty-five consecutive microbial isolates were collected from surgical wounds or abscesses, respiratory, urine, and blood cultures from patients in the surgical intensive care unit (SICU) of a major tertiary medical center. Using Clinical and Laboratory Standards Institute (CLSI) standard methodology and published breakpoints, all aerobic, facultative anaerobic isolates were tested against ceftaroline and selected comparative antimicrobial agents. %26lt;br%26gt;Results: All staphylococcal isolates were susceptible to ceftaroline at a breakpoint of %26lt;= 1.0 mcg/mL. In addition, ceftaroline exhibited excellent activity against all streptococcal clinical isolates and non-ESBL-producing strains of Enterobacteriaceae (93.5%) recovered from SICU patients. Ceftaroline was inactive against ESBL-producing Enterobacteriaceae, Pseudomonas aeruginosa, vancomycin-resistant enterococci, and selective gram-negative anaerobic bacteria. %26lt;br%26gt;Conclusions: At present, ceftaroline is the only cephalosporin agent that is active against community and healthcare-associated MRSA. Further studies are needed to validate the benefit of this novel broad-spectrum anti-infective agent for the treatment of susceptible serious infections in the SICU patient population.

• 出版日期2014-12-1