A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

作者:Brorsson Caroline; Bergholdt Regine; Sjogren Marketa; Eising Stefanie; Sorensen Karina Meden; Hougaard David M; Orho Melander Marju; Groop Leif; Pociot Flemming*
来源:Molecular Genetics and Metabolism, 2008, 94(3): 386-388.
DOI:10.1016/j.ymgme.2008.02.011

摘要

Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.

  • 出版日期2008-7

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