A chiral scandium-complex-catalyzed asymmetric inverse-electron-demand oxa-Diels-Alder reaction of o-quinone methides with fulvenes

作者：Zhang, Jianlin; Lin, Lili^*; He, Changqiang; Xiong, Qian; Liu, Xiaohua; Feng, Xiaoming^*

来源：Chemical Communications, 2018, 54(1): 74-77.

DOI：10.1039/c7cc08124c

• FACILE SYNTHESIS
• ENANTIOSELECTIVE ADDITION
• IN-SITU
• 6+3 CYCLOADDITION
• ACID
• YLIDES
• CONSTRUCTION
• ACTIVATION
• ALCOHOLS

A highly efficient asymmetric inverse-electron-demand oxa-Diels-Alder reaction of o-quinone methides with fulvenes has been realized using a chiral N,N'-dioxide/Sc(III) complex as the catalyst. The corresponding optically active chromane derivatives were obtained in high yields with excellent dr and ee values (up to 99% yield, >19 : 1 dr and 94% ee).

• 出版日期2018-1-4
• 单位四川大学