The application of Morita-Baylis-Hillman reaction: Synthetic studies on perophoramidine

作者：Wu, Lin; Zhang, Qian-Ru; Huang, Ji-Rong; Li, Yang; Su, Fu^*; Dong, Lin^*

来源：Tetrahedron, 2017, 73(27-28): 3966-3972.

DOI：10.1016/j.tet.2017.05.067

• Vicinal quaternary centers
• MBH
• Reductive cyclization
• Allylic alkylation

Anew concise methodology was developed for the synthesis of the two vicinal quaternary centers of the natural product perophoramidine. Key steps involved the Morita-Baylis-Hillman reaction, reductive cyclization and allylic alkylation. Moreover, most conditions are simple and convenient with good yields.

• 出版日期2017-7-6
• 单位四川大学