Different Human Gut Models Reveal the Distinct Fermentation Patterns of Arabinoxylan versus Inulin

作者：Van den Abbeele Pieter; Venema Koen; Van de Wiele Tom^*; Verstraete Willy; Possemiers Sam

来源：Journal of Agricultural and Food Chemistry, 2013, 61(41): 9819-9827.

DOI：10.1021/jf4021784

• bowel
• intestine
• microflora
• fructan
• bacteria

Different in vitro models have been developed to assess how food compounds affect the human gut microbiota. Using two such models (SHIME(R) and TIM-2), we compared how long-chain arabinoxylan (LC-AX), a wheat-derived potentially prebiotic fiber, and inulin (IN), a well-established prebiotic compound, modulate SCFA production and bifidobacteria composition. While both the SHIME and TIM-2 differ in experimental design, they both demonstrated that LC-AX and IN specifically increased the health-promoting metabolites propionate and butyrate, respectively. Furthermore, LC-AX stimulated Bifidobacterium longum, while IN stimulated other bifidobacteria including Bifidobacterium adolescentis. The SHIME experiment also revealed that effects of LC-AX were more persistent during the 2-week wash-out period. These results confirm a recent in vivo study, during which humanized rats were treated with the same LC-AX/IN. In conclusion, results from different human gut models suggest that, besides IN, LC-AX are promising prebiotic candidates with high specificity toward Bifidobacterium longum and a selective propionate increase.

• 出版日期2013-10-16