New Synthetic Strategy for High-Enantiopurity N-Protected alpha-Amino Ketones and their Derivatives by Asymmetric Hydrogenation

作者：Sun Tian; Hou Guohua; Ma Miaofeng; Zhang Xumu^*

来源：Advanced Synthesis & Catalysis, 2011, 353(2-3): 253-256.

DOI：10.1002/adsc.201000680

• alpha-amino ketones
• amphetamines
• enantioselectivity
• hydrogenation
• rhodium

Asymmetric hydrogenation of alpha-dehydroamino ketones catalyzed by a rhodium-chiral phosphorus ligand complex (up to 99% ee, 1000 TON), represents an efficient approach to chiral alpha-amino ketones. The reduction of alpha-amino ketones catalyzed by palladium on carbon (Pd/C) leads to amphetamine precursors with quantitative yield and no significant enantioselectivity loss.

• 出版日期2011-2-11