Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis Specific Immunity in Young Children

作者:Jenum Synne*; Dhanasekaran Sivakumaran; Ritz Christian; Macaden Ragini; Doherty T Mark; Grewal Harleen M S
来源:Pediatric Infectious Disease Journal, 2016, 35(12): 1336-1338.
DOI:10.1097/INF.0000000000001328

摘要

We have explored the added value of interferon-gamma (IFN gamma)-inducible protein 10 as a read-out of Mycobacterium tuberculosis-specific immunity in young Indian children, where the sensitivity of the IFN gamma release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFN gamma/inducible protein 10 read-out in a 4th generation IFN gamma release assays.

  • 出版日期2016-12