Amperometric Sensing of Paracetamol Using a Glassy Carbon Electrode Modified with a Composite of Water-Stable Metal-Organic Framework and Gold Nanoparticles

作者：Shi, Yifei; Zhang, Yubin; Wang, Yang; Huang, Huayu^*; Ma, Junjie

来源：International Journal of Electrochemical Science, 2018, 13(8): 7643-7654.

DOI：10.20964/2018.08.65

• Nanomaterial
• Electrochemical Sensor
• Acetaminophen
• Pharmaceutical analysis

A paracetamol electrochemical sensor was facilely fabricated by modifying a glassy carbon electrode (GCE) with a water-stable metal-organic framework (MOF) and gold nanoparticles (AuNPs). The MOF/AuNP composites were synthesized by hydrothermal and sonication methods. The MOF possesses a high specific area and coordinatively unsaturated sites as an amplification element, and the AuNPs can amplify the electrochemical signal with excellent conductivity intensity. The modification activity of the MOF/AuNP composites was investigated via voltammetric determination of paracetamol. A sensitive paracetamol measurement method was built using the MOF/AuNP modified GCE. The oxide peak response changed linearly as the paracetamol concentration increased from 0.01 nmol L-1 to 100 mu mol L-1, and the low detection limit was 0.0011 nmol L-1 (3 sigma). The present work offers a new method to analyze paracetamol in tablets and expands the application of MOFs in the electrochemical field.

• 出版日期2018-8
• 单位西北大学