Addressable molecular tweezers for DNA-templated coupling reactions

作者：Chhabra Rahul; Sharma Jaswinder; Liu Yan; Yan Hao^*

来源：Nano Letters, 2006, 6(5): 978-983.

DOI：10.1021/nl060212f

Here we report the construction of fully addressable DNA-based molecular tweezers to actuate coupling reactions in a programmable fashion. Three tweezers, each bearing two coupling reactants, are self-assembled on a linear DNA track. A fourth tweezer floating freely in solution can be brought to any one of the tweezers and close them by the addition of a unique pair of "fuel" DNA strands. The coupling reactions happen when the tweezers are closed, and this can be controlled sequentially from one tweezer to another. A molecular device of this kind would not only enable programmable chemical reactions but also allow distance-dependent control of biomolecular interactions.

• 出版日期2006-5