Neovascular invasion of the endothelio-descemetic interface occurring after deep anterior lamellar keratoplasty

作者：Pinsard L^*; Malet F; Colin J; Touboul D

来源：Journal Francais d Ophtalmologie, 2013, 36(5): E77-E81.

DOI：10.1016/j.jfo.2012.08.009

• Neovascularization
• Cornea
• Deep anterior
• lamellar
• keratoplasty
• Bevacizumab
• Thermocauterization
• Rejection
• Avastin
• Inflammation

Introduction. - The endothelio-descemetic interface (EDI) of a deep anterior lamellar keratoplasty (DALK) may become the locus of a neovascular proliferation. Bevacizumab (Avastin) is an antiangiogenic alternative available for curative treatment in deep corneal neovascularization.
Observation. - We report the case of a 49-year-old woman who had received two arcuate relaxing incisions for high astigmatism after DALK. She developed graft rejection associated with significant neovascular stromal invasion in the EDI of the graft-host interface. Two subconjunctival injections of bevacizumab 1 month apart as well as thermocauterization of the feeding vessel were necessary and effective. No recurrence has been observed after 2 years of follow-up.
Discussion. - Corneal neovascularization can be a cause of DALK rejection. A combination of anti-antiangiogenic and physical methods may abort graft rejection and permanently restore graft function.

• 出版日期2013-5