科研之友
微信
新浪微博
Facebook
分享链接
摘要
Carboxylic esters can be readily obtained at low cost. Therefore, asymmetric catalytic activation of esters should provide useful strategies for organic synthesis. Here we report a N-heterocyclic carbene (NHC)-mediated reaction of alpha-aryl acetic esters with oxindole-derived alpha,beta-unsaturated imines. The reaction involves the formation of NHC-bound ester enolate intermediate from an ester as a key step, and furnishes spirocyclic oxindole products. The sterically congested spirocyclic oxindole bears a newly formed six-membered delta-lactams and cannot be easily prepared using other methods.
- 出版日期2013-6
- 单位南阳理工学院
