A histone code for the DNA damage response in mammalian cells?

作者：Corpet Armelle; Almouzni Genevieve^*

来源：The EMBO Journal, 2009, 28(13): 1828-1830.

DOI：10.1038/emboj.2009.180

DNA repair in the context of chromatin represents a challenge both in terms of accessibility to the lesion and maintenance of genome stability. Histones, the main protein component of chromatin, can be subjected to a variety of post-translational modifications (PTMs) that impact on genome function by either directly affecting nucleosome stability or providing a docking site for distinct regulatory proteins. In this issue of EMBO Journal, Tjeertes et al investigate histone PTMs with a specific involvement in the DNA damage response (DDR).

• 出版日期2009-7-8