Phytochemical analysis of bark from Helietta apiculata Benth and antimicrobial activities

作者：Fernandes Tanize S; Copetti Daniele; Do Carmo Gabriele; Neto Alexandre T; Pedroso Marcelo; Silva Ubiratan F; Mostardeiro Marco A; Burrow Robert E; Dalcol Ionara I; Morel Ademir F^*

来源：Phytochemistry, 2017, 141: 131-139.

DOI：10.1016/j.phytochem.2017.05.017

• Helietta apiculata Benth
• Rutaceae
• Chemical constituents
• Antimicrobial
• Alkaloids
• Neolignas
• Coumarins

Extraction and characterization of natural products from the bark of the trunk of Helietta apiculata Benth (Rutaceae) afforded nine alkaloids, eight furoquinoline and one quinolone, limonine, three cinnamic acid derivatives, three neolignans, tetracosanoic acid, six coumarins, of which apiculin A and apiculin B (neolignans), and tanizin (coumarin) are previously undescribed compounds. The structures of all compounds were determined by spectroscopic methods, and the crystal structures of two of the newly undescribed compounds, apiculin A and apiculin B, were determined by X-ray analysis. Extracts and pure compounds isolated from Helietta apiculata showed promising antimicrobial activities.

• 出版日期2017-9