Naja naja karachiensis Envenomation: Biochemical Parameters for Cardiac, Liver, and Renal Damage along with Their Neutralization by Medicinal Plants

作者：Bin Asad Muhammad Hassham Hassan; Murtaza Ghulam^*; Ubaid Muhammad; Durr e Sabih; Sajjad Ashif; Mehmood Rubada; Mahmood Qaisar; Ansari Muhammad Muzzmil; Karim Sabiha; Mehmood Zahid; Hussain Izhar

来源：Biomed Research International, 2014, 970540.

DOI：10.1155/2014/970540

Naja naja karachiensis envenomation was found to hit more drastically heart, liver, and kidneys. 400 mu g/kg of venom-raised moderate serum levels of ALT ( 72 +/- 4.70 U/L, 0.1 > P > 0.05), AST (157 +/- 24.24 U/L, 0.1 > P > 0.05), urea (42 +/- 3.08 mg/dL, 0.05 > P > 0.02), creatinine (1.74 +/- 0.03 mg/dL, 0.01 > P > 0.001), CK-MB (21 +/- 1.5 U/L, 0.05 > P > 0.02), and LDH (2064 +/- 15.98 U/L, P< 0.001) were injected in experimental rabbits. However, lethality was enhanced with 800 Pg/kg of venom in terms of significant release of ALT (86 +/- 5.0 U/L, 0.05 > P > 0.02), AST (251 +/- 18.2 U/L, 0.01 > P > 0.001), urea (57.6 +/- 3.84 mg/dL, 0.02 > P > 0.01), creatinine (2.1 +/- 0.10 mg/dL, 0.02 > P > 0.01), CK-MB (77 +/- 11.22 U/L, 0.05 > P > 0.02), and LDH (2562 +/- 25.14 U/L, P << 0.001). Among twenty-eight tested medicinal plant extracts, only Stenolobium stans (L.) Seem was found the best antivenom (P > 0.5) compared to the efficacy of standard antidote (ALT = 52.5 +/- 3.51 U/L, AST = 69.5 +/- 18.55 U/L, urea = 31.5 +/- 0.50 mg/dL, creatinine = 1.08 +/- 0.02 mg/dL, CK-MB = 09 +/- 0.85 U/L, and LDH = 763 +/- 6.01 U/L). Other plant extracts were proved less beneficial and partly neutralized the toxicities posed by cobra venom. However, it is essential in future to isolate and characterize bioactive compound(s) from Stenolobium stans (L.) Seem extract to overcome the complications of snake bite.

• 出版日期2014