H2SO4-Promoted Synthesis of (E)-Stilbenes from Substituted Phenylacetones and Substituted Benzaldehydes Through Tandem Aldol-Grob Reaction

作者：Narender T^*; Reddy K Papi; Tiwari Sriniwas

来源：Synthetic Communications, 2011, 41(11): 1572-1583.

DOI：10.1080/00397911.2010.488309

• (E)-Stilbenes
• H2SO4
• phenylacetones
• 1-phenylpropan-2-one

[image omitted] Stilbene derivates (stilbenoids) are present in plants and show a wide range of biological activities and potential therapeutic value. In continuation of our natural product synthesis program, an efficient, simple, and practical method has been developed to regioselectively synthesize (E)-stilbenes using H2SO4 as a catalyst in a short time (30-60s) at room temperature in good to excellent yields.

• 出版日期2011