Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding

作者：Xue Yali; Prado Martinez Javier; Sudmant Peter H; Narasimhan Vagheesh; Ayub Qasim; Szpak Michal; Frandsen Peter; Chen Yuan; Yngvadottir Bryndis; Cooper David N; de Manuel Marc; Hernandez Rodriguez Jessica; Lobon Irene; Siegismund Hans R; Pagani Luca; Quail Michael A; Hvilsom Christina; Mudakikwa Antoine; Eichler Evan E; Cranfield Michael R; Marques Bonet Tomas; Tyler Smith Chris^*; Scally Aylwyn

来源：Science, 2015, 348(6231): 242-245.

DOI：10.1126/science.aaa3952

Mountain gorillas are an endangered great ape subspecies and a prominent focus for conservation, yet we know little about their genomic diversity and evolutionary past. We sequenced whole genomes from multiple wild individuals and compared the genomes of all four Gorilla subspecies. We found that the two eastern subspecies have experienced a prolonged population decline over the past 100,000 years, resulting in very low genetic diversity and an increased overall burden of deleterious variation. A further recent decline in the mountain gorilla population has led to extensive inbreeding, such that individuals are typically homozygous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from the population. We discuss the causes of their decline and the consequences for their future survival.

• 出版日期2015-4-10
• 单位河北医科大学