Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989 and 2011

作者：Khor Chee Sieng; Sam I Ching; Hooi Poh Sim; Chan Yoke Fun^*

来源：Infection, Genetics and Evolution, 2013, 14: 357-360.

DOI：10.1016/j.meegid.2012.12.017

• Human respiratory syncytial virus
• Molecular epidemiology
• Genotype
• Malaysia

From 1989 to 2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17 years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal clustering with RSV strains reported in previous epidemiological studies. Every few years, the existing predominant genotype was replaced by a new genotype. The RSV-A genotypes GA2, GA5 and GA7 were replaced by NA1 and NA2, while BA became the predominant RSV-B genotype. A unique local cluster, BA12, was seen in 2009, and the recently-described ON1 genotype with 72-nt duplication emerged in 2011. Our findings will have important implications for future vaccine intervention.

• 出版日期2013-3