Application of Turbulent Flow Chromatography Load Columns for the On-Line Analysis of Anti-Infectives in Wastewaters

作者：Segura Pedro A; Gagnon Christian; Sauve Sebastien^*

来源：Chromatographia, 2009, 70(1-2): 239-245.

DOI：10.1365/s10337-009-1097-9

• Column liquid chromatography-mass spectrometry
• Turbulent flow chromatography
• On-line preconcentration
• Anti-infectives in wastewater

We developed an on-line preconcentration liquid chromatography-tandem mass spectrometry method for the determination of the anti-infectives sulfamethoxazole, trimethoprim, ciprofloxacin, levofloxacin, clarithromycin and azithromycin in wastewaters using a turbulent flow chromatography load column. Recoveries for the target analytes were between 86 and 141%. Limits of quantification ranged from 45 to 122 ng L(-1) and limits of confirmation from 37 to 142 ng L(-1). This study shows that turbulent flow chromatography load columns are an interesting alternative for the on-line preconcentration of wastewater samples because they can be loaded at higher flow rates and are less affected by fouling, thus decreasing analysis time and enhancing method robustness necessary for the analysis of environmental trace pollutants.

• 出版日期2009-7