Agarose Gel Investigation of Quantum Dots Conjugated With Short ssDNA

作者：Wu Tsai Chin^*; Dutta Mitra; Stroscio Michael A

来源：IEEE Transactions on NanoBioscience, 2013, 12(4): 282-288.

DOI：10.1109/TNB.2013.2268540

• DNA
• double layer
• gel electrophoresis
• quantum dots
• Smoluchowski equation

Herein, we investigate the migration distance of quantum-dot-functionalized complexes in electrophoresis. The quantitative study of these moving particles in an electrophoretic environment is modeled using an extended Smoluchowski equation. An extended Smoluchowski equation is proposed to addressed the D-m to Ln(N) plot slope variation issue present in previous work and agreement between expeiment and theory is found. The procedures underlying this work then discusses the potential of using agarose electrophoresis as a mean of monitoring the composition of nano-complexes consisting of quantum dots functionalized with differing numbers of DNA molecules.

• 出版日期2013-12