An Enantioselective Synthesis of (+)-Polyoxamic Acid via Phase-Transfer Catalytic Conjugate Addition and Asymmetric Dihydroxylation

作者：Lee Yeon Ju; Park Yohan; Kim Mi hyun; Jew Sang sup; Park Hyeung geun^*

来源：Journal of Organic Chemistry, 2011, 76(2): 740-743.

DOI：10.1021/jo102272h

A new enantioselective synthetic method of (+)-polyoxamic acid is reported. (+)-Polyoxamic acid could be obtained in 7 steps with 46% overall yield from diphenylmethyl-glycineimine tert-butyl ester via an enantioselective phase-transfer conjugate addition (99% yield, 96% ee) and an asymmetric dihydroxylation (98% yield, 94% de) as the key reactions.

• 出版日期2011-1-21