High Expression of Lewis y Antigen and CD44 Is Correlated with Resistance to Chemotherapy in Epithelial Ovarian Cancers

作者：Hu, Zhenhua; Gao, Jian; Zhang, Danye; Liu, Qing; Yan, Limei; Gao, Lili; Liu, Juanjuan; Liu, Dawo; Zhang, Shulan; Lin, Bei^*

来源：PLos One, 2013, 8(2): e57250.

DOI：10.1371/journal.pone.0057250

• GROWTH-FACTOR RECEPTOR
• RMG-1 CELLS
• PROMOTES RESISTANCE
• DRUG-RESISTANCE
• APOPTOSIS
• GLYCOSYLATION
• TRANSFECTION
• HYALURONAN
• CARBOPLATIN
• BREAST

Objectives: To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.
Methods: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).
Results: The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.
Conclusions: Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.

• 出版日期2013-2-28
• 单位中国医科大学