Dose-dependent response of serum lutein and macular pigment optical density to supplementation with lutein esters

作者：Bone Richard A^*; Landrum John T

来源：Archives of Biochemistry and Biophysics, 2010, 504(1): 50-55.

DOI：10.1016/j.abb.2010.06.019

• Lutein
• Macular pigment
• Carotenoids
• Heterochromatic flicker photometry
• Supplementation
• AMD

We conducted a study to determine the effect of different doses of a lutein supplement on serum lutein concentration and macular pigment optical density (MPOD). Lutein is one of the major components of human macular pigment. Eighty-seven subjects received daily doses of 5, 10, or 20 mg of lutein, or a placebo, over a 140 day period. Serum lutein concentration was determined by HPLC and MPOD by heterochromatic flicker photometry (HFP). Serum lutein responded positively, except in the placebo group, reaching a plateau that, averaged for each dosage group, was linearly dependent on dose. Likewise MPOD, on average, increased at a rate that varied linearly with dose. For subjects deemed more proficient at HFP, approximately 29% of the variability in MPOD response could be attributed to a linear dependence on the fractional change in serum lutein concentration. We did not detect any significant influence of age on serum lutein uptake or MPOD response.

• 出版日期2010-12-1