AID expression during B-cell development: searching for answers

作者：Kuraoka Masayuki; McWilliams Laurie; Kelsoe Garnett^*

来源：Immunologic Research, 2011, 49(1-3): 3-13.

DOI：10.1007/s12026-010-8185-7

• Activation-induced cytidine deaminase
• B-cell development
• Class switch recombination deficiency
• Somatic hypermutation
• Germinal center

Expression of activation-induced cytidine deaminase (AID) by germinal center (GC) B cells drives the processes of immunoglobulin (Ig) somatic hypermutation (SHM) and class switch recombination (CSR) necessary for the generation of high affinity IgG serum antibody and the memory B-cell compartment. Increasing evidence indicates that AID is also expressed at low levels in developing B cells but to date, this early, developmentally regulated AID expression has no known function. Does the timing and extent of AID expression in developmentally immature, non-GC B cells provide clues to reveal its physiologic role?.

• 出版日期2011-4