A Rash Hypothesis

作者：Liu Anne Y; Lowe Robert C; Levy Bruce D; Katz Joel T^*; Loscalzo Joseph

来源：New England Journal of Medicine, 2010, 363(1): 72-78.

DOI：10.1056/NEJMcps0708369

A 40-year-old woman presented with diarrhea, reporting to her physician that she had been having loose stools for 2 years, with 4 to 5 bowel movements per day, progressing over the previous 6 months to 15 large-volume, watery stools daily, including nocturnal stools. Abdominal cramps preceded these episodes and were partially relieved by bowel movements. Loperamide increased stool bulk but did not alter frequency. She noted no blood or oil in the stool. She had also been vomiting over the previous 2 months, more recently up to four times daily. The frequency of her diarrhea was not affected by food intake, although eating often precipitated vomiting. Despite a weight loss of nearly 7 kg (15 lb) in the previous 6 months, her abdominal girth had increased. She noted occasional palpitations and headaches but no fevers, night sweats, hematemesis, cough, or shortness of breath.

• 出版日期2010-7-1