ARTIFICIAL MACROSPHELIDES AS A NOVEL APOPTOSIS-INDUCING COMPOUND

作者：Matsuya Yuji^*; Nemoto Hideo

来源：Heterocycles, 2010, 81(1): 57-66.

DOI：10.3987/REV-09-660

• Macrosphelide
• Ring-Closing Metathesis
• Thiazole Side-Chain
• Epothilone
• Apoptosis

Natural 16-membered macrolide compounds, macrosphelides, have recently been disclosed to exert an apoptosis-inducing effect against human lymphoma U937 cells. In this review, molecular design, syntheses, and biological evaluation of artificial macrosphelides are surveyed, focusing on their apoptosis-inducing activity.

• 出版日期2010-1-1