Association of Inflammation Genes with Alcohol Dependence/Abuse: A Systematic Review and a Meta-Analysis

作者：Kebir Oussama; Gorsane Mohamed Ali; Blecha Lisa; Krebs Marie Odile; Reynaud Michel; Benyamina Amine^*

来源：European Addiction Research, 2011, 17(3): 146-153.

DOI：10.1159/000324849

• Alcohol abuse
• Alcohol dependence
• Genetic association
• Inflammation
• Interleukin
• TNF-alpha
• Meta-analysis

The aim of the present work was to systematically review all association studies of inflammation genes with alcohol dependence/alcohol abuse (AD/AA) and to perform a meta-analysis. Odds ratios (ORs) were estimated by contrasting the ratio of counts of the 'high-risk' versus 'low-risk' alleles in AD/AA cases versus controls. Data reported in at least three published studies were available for four genetic polymorphisms [TNF-alpha -238 (rs361525, G/A); TNF-alpha -308 (rs1800629, G/A); IL-1RA (VNTR [86 bp](n)); IL-10 -592 (rs1800896, C/A)]. In total, nine meta-analyses were performed. Of these, only the TNF-alpha -238 polymorphism showed a significant association with AD/AA (OR = 1.36, 95% Cl: 1.05-1.76). This risk remained significant and increased slightly when we considered only patients with advanced alcohol-related liver disease (AALD) (OR = 1.5, 95% Cl: 1.13-1.98) but not when we considered only patients without AALD (OR = 1.08, 95% CI: 0.5-2.35). Sensitivity analysis showed that this genetic association is derived from the AALD phenotype rather than from AD. Our approach is limited by our phenotype definition; some studies included chronic heavy drinkers (minimal daily consumption of 80 g for a minimal duration of 10 years) but without a standardized psychiatric assessment.

• 出版日期2011