Differential Expression of the Eicosanoid Pathway in Patients With Localized or Mucosal Cutaneous Leishmaniasis

作者：Franca Costa Jaqueline; Andrade Bruno B; Khouri Ricardo; Van Weyenbergh Johan; Malta Santos Hayna; Santos Claire da Silva; Brodyskn Claudia I; Costa Jackson M; Barral Aldina; Bozza Patricia T; Boaventura Viviane; Borges Valeria M^*

来源：Journal of Infectious Diseases, 2016, 213(7): 1143-1147.

DOI：10.1093/infdis/jiv548

• tegumentary leishmaniasis
• inflammation
• eicosanoids
• prostaglandin
• leukotrienes
• biomarkers

Unfettered inflammation is thought to play critical role in the development of different clinical forms of tegumentary leishmaniasis. Eicosanoids are potent mediators of inflammation and tightly associated with modulation of immune responses. In this cross-sectional exploratory study, we addressed whether targets from the eicosanoid biosynthetic pathway, assessed by multiplexed expression assays in lesion biopsy and plasma specimens, could highlight a distinct biosignature in patients with mucocutaneous leishmaniasis (MCL) or localized cutaneous leishmaniasis (LCL). Differences in immunopathogenesis between MCL and LCL may result from an imbalance between prostaglandins and leukotrienes, which may serve as targets for future host-directed therapies.

• 出版日期2016-4-1
• 单位河北医科大学