A multifunctional sensor-chip based on micromachined chamber array

作者：Zhu JZ; Zhu ZQ; Lai ZS; Wang R; Wu XQ; Zhang GX; Zhang ZR

来源：Sensors and Materials, 2002, 14(4): 209-218.

• biosensor
• potassium ion-selective-electrode
• micromachining technology
• chitosan membrane

This paper reports the fabrication and characterization of a sensor-chip based on a 2x2 microchamber array produced on silicon by anisotropic etching. The chip consists of a glucose sensor, a glutamate sensor, a galactose sensor and a potassium ion-selective-electrode. The structure of the microchamber-array has improved membrane adhesion and mechanical stability and can offer the place-selective immobilization of the, enzymes. A chitosan membrane is used not only to immobilize the enzyme on the working electrode but also to prevent the penetration of interferents such as uric and ascorbic acids. The fabricated chips have shown attractive performances such as high sensitivity and good stability.

• 出版日期2002
• 单位上海师范大学