Facile synthesis of pyrazolo[1,5-a]pyrimidine derivatives via microwave irradiation and biological activity research

作者：Li M^*; Guo WS; Wen LR; Yang HZ

来源：Chinese Journal of Organic Chemistry, 2005, 25(10): 1230-1234.

• pyrazolo[1,5-a]pyrimidine
• enaminone
• microwave irradiation
• synthesis
• biological activity

A series of 2-methylthio-3-cyano-7-substituted pyrazolo[1,5-a]pyrimidines (3a similar to 3f) by the reaction of substituted enaminones 1 with 3-methylthio-4-cyano-5-amino-1H-pyrazole (2) have been conveniently synthesized via conventional method and microwave irradiation technique. By comparison of the two methods, microwave irradiation possessed such advantages as short reaction time, environmentally benign procedures, easy purification and high yield over the conventional stirring at ambient temperature. The structure of all compounds was characterized by elemental analyses, IR, H-1 NMR spectra. In the meantime, the plausible mechanism was discussed. The preliminary test showed that certain compounds had somewhat herbicidal activities.

• 出版日期2005-10
• 单位青岛大学