Antibacterial activity of MgO nanoparticles based on lipid peroxidation by oxygen vacancy

作者：Krishnamoorthy Karthikeyan; Manivannan Govindasamy; Kim Sang Jae; Jeyasubramanian Kadarkaraithangam; Premanathan Mariappan^*

来源：Journal of Nanoparticle Research, 2012, 14(9): 1063.

DOI：10.1007/s11051-012-1063-6

• MgO nanoparticles
• Antibacterial activity
• Lipid peroxidation
• ROS generation
• Oxygen vacancy
• Resazurin

Antibacterial activity of MgO nanoparticles (NPs) was evaluated against the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa as well as the Gram-positive bacterium Staphylococcus aureus by microtitre plate-based assay incorporating resazurin as an indicator of cell growth. MgO NPs exhibited antibacterial activity with minimal inhibitory concentration of 500 lg/mL against E. coli and 1,000 lg/mL for P. aeruginosa and S. aureus. MgO NPs enhanced ultrasound-induced lipid peroxidation in the liposomal membrane. It was suggested that the mechanism of the antibacterial activity of the MgO NPs relied on the presence of defects or oxygen vacancy at the surface of the nanoparticle which led to the lipid peroxidation and reactive oxygen species generation.

• 出版日期2012-9