Anti-Mullerian hormone as an ovarian reserve marker in young cancer women who undergo ovarian tissue cryopreservation

作者：Fabbri Raffaella^*; Macciocca Maria; Melotti Cristina; Pasquinelli Gianandrea; Vicenti Rossella; Reggiani Maria Letizia Bacchi; Terribile Daniela; Venturoli Stefano

来源：Future Oncology, 2014, 10(8): 1343-1351.

DOI：10.2217/FON.14.76

• anti-Mullerian hormone
• menstrual cycle
• ovarian reserve
• ovarian tissue cryopreservation
• primordial follicles

Aim: To evaluate if anti-Mullerian hormone (AMH) is a reliable marker of ovarian reserve in young women undergoing ovarian tissue cryopreservation. Patients %26 methods: Relationships of serum AMH levels with primordial follicle density, age and reproductive hormones were investigated using the Pearson or Spearman correlation coefficient in 86 women with cancer (12-38 years) undergoing ovarian tissue cryopreservation. AMH variations through the menstrual cycle were assessed by the Kruskal-Wallis test. p %26lt; 0.05 was accepted as significant. Results: AMH positively correlated with primordial follicle density (p = 0.03), showed great interindividual variability at all ages and negatively correlated with estradiol (p = 0.007) in the early follicular phase. AMH did not vary across the menstrual cycle (p = 0.415). Conclusion: AMH appears a valid ovarian reserve marker in young cancer women.

• 出版日期2014-6