A direct synthetic route to fused tricyclic quinolones from 2,3-diaminoquinolin-4(1H)one

作者:Maurino Reyes Enrique de J; Gonzalez Rodriguez Edgar; Reyes Rangel Francisco; Lira Rocha Alfonso*; Loza Mejia Marco A
来源:Heterocyclic Communications, 2016, 22(3): 169-173.
DOI:10.1515/hc-2016-0059

摘要

Fused tricyclic heterocycles are useful compounds in many areas of chemistry. In this study, 2,3-diaminoquinolin-4(1H) one (5), a key intermediate for the preparation of tricyclic compounds, was prepared from isatoic anhydride in four steps with high yields under mild conditions and an easy workup, with most of the reactions carried out in aqueous medium. Compound 5 was transformed into a series of tricyclic fused products 8 and 9.

  • 出版日期2016-6