Controllable delivery of peptides by superparamagnetic Fe3O4/slica nanoparticle vehicles

作者：Zhang, Wenting; Liu, Xiaofang; Zhao, Xiaoning; Zhang, Xuefeng^*

来源：Materials Letters, 2017, 201: 177-180.

DOI：10.1016/j.matlet.2017.05.020

• Fe3O4/slica
• Nanoparticles
• Nano-vehicle
• Delivery
• Functional

Superparamagnetic core shell nanoparticles, composed of Fe3O4 cores and biocompatible slica shells, have been utilized as a nano-vehicle for the delivery of peptides. The silica shells with amine groups were functionalized with 1,2-cyclohexanedicarboxylic anhydride as click linkers, forming pH-sensitive amides and terminal carboxylic groups for the conjugation and release of bradykinin B1 receptor antagonist (R-954) peptides. The results show that the loading capacity of R-954 can reach up to 19.8 wt.% of the total mass of Fe3O4/silica/R-954 nanoparticles, which is far higher than non-chemical binding adsorption (1.2 wt.%). In this case, similar to 92.3% peptides could be released at pH 5.0 for about 5 h, while only 10.2% occured at pH 7.4. Meanwhile such nanovehicles present a monodispersibility in aqueous solution and thus have a great potential for their use as delivery systems.

• 出版日期2017-8-15
• 单位东北大学