An N-Terminal Amphipathic Helix in Dengue Virus Nonstructural Protein 4A Mediates Oligomerization and Is Essential for Replication

作者：Stern Omer; Hung Yu Fu; Valdau Olga; Yaffe Yakey; Harris Eva; Hoffmann Silke; Willbold Dieter; Sklan Ella H^*

来源：Journal of Virology, 2013, 87(7): 4080-4085.

DOI：10.1128/JVI.01900-12

Dengue virus (DENV) causes dengue fever, a major health concern worldwide. We identified an amphipathic helix (AH) in the N-terminal region of the viral nonstructural protein 4A (NS4A). Disruption of its amphipathic nature using mutagenesis reduced homo-oligomerization and abolished viral replication. These data emphasize the significance of NS4A in the life cycle of the dengue virus and demarcate it as a target for the design of novel antiviral therapy.

• 出版日期2013-4