Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

作者：Hsieh Yi Chen^*; Hsieh Fang I; Chen Yih Ru; Hu Chaur Jong; Jeng Jiann Shing; Tang Sung Chun; Chi Nai Fang; Lin Huey Juan; Lien Li Ming; Peng Giia Sheun; Chiou Hung Yi^*

来源：Journal of Biomedical Science, 2017, 24(1): 25.

DOI：10.1186/s12929-017-0332-1

• Ischemic stroke
• Estradiol
• Inflammation
• Polygenic risk score

Background: Estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes and estradiol levels on the risk of ischemic stroke.
Methods: This case-control study was conducted with 624 ischemic stroke patients and 624 age-and gender-matched controls. The PRS estimated the polygenic contribution of inflammatory genes from ischemic stroke susceptibility loci. Estradiol levels were measured using a radioimmunoassay. High and low estradiol levels were defined according to the log-transformed median estradiol levels in female and male controls.
Results: Subjects in the fourth quartile of the PRS had a significant 1.57-fold risk of ischemic stroke (95% confidence interval [CI], 1.12 similar to 2.19), after adjusting for covariates compared to individuals in the lowest quartile. Compared to individuals with high estradiol levels and a low PRS as the reference group, those exposed to low estradiol levels and a high PRS had an increased risk of ischemic stroke (odds ratio, 3.35; 95% CI, 1.79 similar to 6.28). Similar results were also observed in males when the analysis was stratified by gender.
Conclusions: Our data suggest that the PRS can be useful in evaluating a high risk of ischemic stroke among patients, especially those exposed to low estradiol levels.

• 出版日期2017-3-28