Densely functionalized 1,2-dihydrobenzo[b] [1,6]naphthyridines: one-pot synthesis via sequential Ugi and Heck reactions

作者：Asthana Mrityunjaya; Sharma Neha; Singh Radhey M^*

来源：Tetrahedron, 2014, 70(43): 7996-8003.

DOI：10.1016/j.tet.2014.08.046

• Benzo[b][1,6]naphthyridines
• One-pot
• Ugi reaction
• Heck reaction
• Functionalized

A facile one-pot synthesis of functionalized 1,2-dihydrobenzo[b][1,6]naphthyridines is described via sequential Ugi four components using 2-chloroquinoline-3-carboxaldehydes, allyi amine, acetic acid, isocyanides and ligand free Heck reactions in good yields.

• 出版日期2014-10-28