PLMA-b-POEGMA amphiphilic block copolymers: Synthesis and self-assembly in aqueous media

作者：Skandalis Athanasios; Pispas Stergios

来源：Journal of Polymer Science Part A: Polymer Chemistry , 2017, 55(1): 155-163.

DOI：10.1002/pola.28379

<jats:title>ABSTRACT</jats:title><jats:p>The synthesis and self‐assembly properties in aqueous solutions of novel amphiphilic block copolymers composed of one hydrophobic poly (lauryl methacrylate), (PLMA) block and one hydrophilic poly (oligo ethylene glycol methacrylate) (POEGMA) block are reported. The block copolymers were prepared by RAFT polymerization and were molecularly characterized by size exclusion chromatography, NMR and FT‐IR spectroscopy, and DSC. The PLMA‐b‐POEGMA amphiphilic block copolymers self‐assemble in nanosized complex nanostructures resembling compound micelles when inserted in aqueous media, as supported by light scattering and TEM measurements. The encapsulation and release of the model, hydrophobic, nonsteroidal anti‐inflammatory drug indomethacin in the polymeric micelles is also investigated.

• 出版日期2017-1-1