A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size

作者：Bond J; Roberts E; Springell K; Lizarraga S; Scott S; Higgins J; Hampshire DJ; Morrison EE; Leal GF; Silva EO; Costa SMR; Baralle D; Raponi M; Karbani G; Rashid Y; Jafri H; Bennett C; Corry P; Walsh CA; Woods CG^*

来源：Nature Genetics, 2005, 37(4): 353-355.

DOI：10.1038/ng1539

Autosomal recessive primary microcephaly is a potential model in which to research genes involved in human brain growth. We show that two forms of the disorder result from homozygous mutations in the genes CDK5RAP2 and CENPJ. We found neuroepithelial expression of the genes during prenatal neurogenesis and protein localization to the spindle poles of mitotic cells, suggesting that a centrosomal mechanism controls neuron number in the developing mammalian brain.

• 出版日期2005-4
• 单位河北医科大学