A Facile One-Pot Synthesis of Chloropyridines from Chalcones

作者:Menon Prasanth K; Krishnaraj K U; George Sholly C; Devaky K S*; Anabha E R
来源:Journal of Heterocyclic Chemistry, 2014, 51(5): 1385-1389.
DOI:10.1002/jhet.1790

摘要

Malononitrile undergoes Michael addition to iminoalkylated chalcones under Vilsmeier-Haack reaction condition. In situ intramolecular cyclization followed by aromatization of the adduct resulted in the formation of 4,6-bis(aryl)-2-chloropyridines in good yields.

  • 出版日期2014-9