Nanofibre optic force transducers with sub-piconewton resolution via near-field plasmon-dielectric interactions

作者：Huang Qian; Lee Joon; Arce Fernando Teran; Yoon Ilsun; Angsantikul Pavimol; Liu Justin; Shi Yuesong; Villanueva Josh; Thamphiwatana Soracha; Ma Xuanyi; Zhang Liangfang; Chen Shaochen; Lal Ratnesh; Sirbuly Donald J^*

来源：Nature Photonics, 2017, 11(6): 352-+.

DOI：10.1038/NPHOTON.2017.74

Ultrasensitive nanomechanical instruments, including the atomic force microscope (AFM)(1-4) and optical and magnetic tweezers(5-8), have helped shed new light on the complex mechanical environments of biological processes. However, it is difficult to scale down the size of these instruments due to their feedback mechanisms9, which, if overcome, would enable high-density nanomechanical probing inside materials. A variety of molecular force probes including mechanophores(10), quantum dots(11), fluorescent pairs(12,13) and molecular rotors(14-16) have been designed to measure intracellular stresses; however, fluorescence-based techniques can have short operating times due to photo-instability and it is still challenging to quantify the forces with high spatial and mechanical resolution. Here, we develop a compact nanofibre optic force transducer (NOFT) that utilizes strong near-field plasmon-dielectric interactions to measure local forces with a sensitivity of <200 fN. The NOFT system is tested by monitoring bacterial motion and heart-cell beating as well as detecting infrasound power in solution.

• 出版日期2017-6