An Efficient Synthesis of 2-Aminothiophenes via the Gewald Reaction Catalyzed by an N-Methylpiperazine-Functionalized Polyacrylonitrile Fiber

作者：Ma Lichao^*; Yuan Liwei; Xu Changzhu; Li Guowei; Tao Minli; Zhang Wenqin

来源：Synthesis (Germany), 2013, 45(1): 45-52.

DOI：10.1055/s-0032-1316821

• Gewald reaction
• 2-aminothiophene
• N-methylpiperazine
• polyacrylonitrile fiber
• fiber catalyst

A new N-methylpiperazine-functionalized polyacrylonitrile fiber has been developed to catalyze the Gewald reaction between 2,5-dihydroxy-1,4-dithiane and activated nitriles to afford 3-substituted 2-aminothiophenes in good to excellent yields (65-91%). Low catalyst loading (8.0 mol%), simple procedure, high yields, excellent recyclability, and reusability (up to 10 times with minimal loss of catalytic activity) are attractive features of this fiber catalyst.

• 出版日期2013-1
• 单位天津大学