ADIPOQ polymorphisms are associated with insulin resistance in Japanese women

作者：Kitamoto Aya; Kitamoto Takuya; So Rina; Matsuo Tomoaki; Nakata Yoshio; Hyogo Hideyuki; Ochi Hidenori; Nakamura Takahiro; Kamohara Seika; Miyatake Nobuyuki; Kotani Kazuaki; Mineo Ikuo; Wada Jun; Ogawa Yuji; Yoneda Masato; Nakajima Atsushi; Funahashi Tohru; Miyazaki Shigeru; Tokunaga Katsuto; Masuzaki Hiroaki; Ueno Takato; Chayama Kazuaki; Hamaguchi Kazayuki; Yamada Kentaro; Hanafusa Toshiaki; Oikawa Shinichi; Sakata Toshiie; Tanaka Kiyoji; Matsuzawa Yuji

来源：Endocrine Journal, 2015, 62(6): 513-521.

DOI：10.1507/endocrj.ej14-0574

• ADIPOQ
• Single nucleotide polymorphism
• Visceral adipose tissue
• Insulin resistance
• Adiponectin

Visceral fat accumulation contributes to the development of insulin resistance, leading to metabolic syndrome. Adiponectin provides a link between visceral fat accumulation and insulin resistance. In addition to environmental factors, genetic factors play important roles in visceral fat accumulation and circulating adiponectin levels. Genome-wide association studies (GWASs) have identified genetic variations in the adiponectin, C1Q and collagen domain containing (ADIPOQ) gene that are associated with adiponectin levels. In this study, we investigated whether ADIPOQ single nucleotide polymorphisms (SNPs) were associated with visceral fat accumulation and insulin resistance. We measured the visceral fat area (VFA) by computed tomography (CT) and examined the presence of the insulin resistance-related phenotype (fasting plasma glucose, fasting insulin, and homeostasis model assessment-insulin resistance [HOMA-IR]) in a set of Japanese individuals (731 men and 864 women) who were genotyped for seven ADIPOQ SNPs reported by recent GWASs (namely, rs6810075, rs10937273, rs1648707, rs864265, rs182052, rs17366568, and rs6773957). SNPs associated with the phenotype (P < 0.05) were then evaluated by association analysis using a second set of the study participants (383 men and 510 women). None of the SNPs was associated with body mass index (BMI) or VFA in men or women. However, the adiponectin-decreasing alleles of rs10937273 and rs1648707 were significantly associated with HOMA-IR (P = 0.0030 and P = 0.00074, respectively) in women, independently of BMI. These SNPs were significantly associated with decreased adiponectin levels in women. Our results suggested that rs10937273 and rs1648707 may affect insulin sensitivity by regulating adiponectin production by adipose tissue in women.

• 出版日期2015-6-20