Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

作者：Mahon Andrew B; Arora Paramjit S^*

来源：Chemical communications, 2012, 48(10): 1416-1418.

DOI：10.1039/c1cc14730g

Appropriately-placed hydrogen bond surrogates have been demonstrated to efficiently nucleate helical conformations. Herein we describe an efficient method for the synthesis of thioether-based hydrogen bond surrogate (teHBS) helices. A teHBS helix is shown to adopt a stable conformation and target its cognate protein receptor with high affinity.

• 出版日期2012