MRI contrast agent delivery using spore capsules: controlled release in blood plasma

作者：Lorch Mark; Thomasson Matthew J; Diego Taboada Alberto; Barrier Sylvain; Atkin Stephen L; Mackenzie Grahame; Archibald Stephen J^*

来源：Chemical Communications, 2009, (42): 6442-6444.

DOI：10.1039/b909551a

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.

• 出版日期2009