A preliminary report of increased plasma levels of IL-33 in bipolar disorder: Further evidence of pro-inflammatory status

作者：Barbosa Izabela Guimaraes^*; Morato Isabela Boechat; de Miranda Aline Silva; Bauer Moises Evandro; Soares Jair C; Teixeira Antonio Lucio

来源：Journal of Affective Disorders, 2014, 157: 41-44.

DOI：10.1016/j.jad.2013.12.042

• Bipolar disorder
• Mania
• Depression
• IL-33
• sST2

Background: Recent findings suggest an important role for inflammation in the neurobiology of bipolar disorder (BD). Interleukin 33 (IL-33) is a cytokine with multiple functions and may act as a nuclear factor regulating transcription and as an %26quot;alarmin%26quot;. IL-33 exerts part of its function through the receptor ST2 that also exists in a soluble form (sST2). This study was performed to evaluate IL-33 and sST2 plasma levels in BD patients. %26lt;br%26gt;Methods: We evaluated IL33 and sST2 plasma levels of 46 BD patients (23 in euthymia and 23 in mania) and 23 healthy controls using enzyme-linked immunosorbent assay (ELISA). BD patients were age and gender matched healthy controls. %26lt;br%26gt;Results: IL-33 levels were higher in BD patients (p=0.02) but there was no difference in sST2 (p=0.55). IL33 and sST2 plasma levels were not correlated with age, neither was influenced by clinical comorbidities nor medications in use. %26lt;br%26gt;Conclusion: These findings corroborate the view of BD as a multisystem condition with a proinflammatory profile.

• 出版日期2014-3-20